<![CDATA[The rise in antimicrobial resistance has prompted the search for potent antimicrobial agents, with plants from unique environments, such as geothermal areas, offering potential due to their diverse phytochemical profiles. This study evaluated the antiplanktonic and antibiofilm activity of M. edule fractions from the geothermal area, Jaboi, Sabang. Crude extracts of M. edule were sequentially fractionated using hexane, ethyl acetate, and ethanol. The resulting fractions were further analyzed for their phytochemical content and antiplanktonic and antibiofilm activities. The ethyl acetate fraction demonstrated superior antiplanktonic and antibiofilm activities compared to other fractions, inhibiting 50% of Pseudomonas aeruginosa planktonic and biofilm formation at a concentration of 10 mg/mL. The most potent fraction exhibited the phenolic content, 672.84 mg GAE/g extract, surpassing the other fractions. The GC-MS analysis shows the presence of pyrogallol, hexadecanoic acid, cedran-diol, and sitosterol. These findings highlight the potential of the ethyl acetate fraction of M. edule as a source of bioactive compounds with promising antiplanktonic and antibiofilm properties, laying the groundwork for future research into its therapeutic applications against biofilm-associated infections.]]>
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