Acute Kidney Injury with Characteristics of Rapidly Progressive Glomerulonephritis Due to Suspected IgA Nephropathy: A Case Report

Sandra Yuliana Andini Putri (General Practicioner, Department of Internal Medicine, West Nusa Tenggara General Hospital, Mataram, Indonesia)
Nadhila Aditiyaputri (General Practicioner, Department of Internal Medicine, West Nusa Tenggara General Hospital, Mataram, Indonesia)
Amanukarti Resi Oetomo (Division of Nephrology & Hypertension, Department of Internal Medicine, West Nusa Tenggara General Hospital, Mataram, Indonesia)

Indonesian Journal of Kidney and Hypertension
Vol 1 No 3 (2024): Volume 1 No. 3, December 2024

Acute kidney damage (AKI) in glomerular disease is typically characterized by rapidly progressive glomerulonephritis (RPGN). RPGN in IgA nephropathy is uncommon, occurring in less than 10% of patients. RPGN presents diagnostic issues in resource-limited settings. A 34-year-old male patient had acute kidney injury with RPGN characteristics based on clinical symptoms of hypertension, pitting edema, anuria, and hematuria after an upper respiratory tract infection, as well as laboratory findings of proteinuria, persistent microscopic hematuria, and positive erythrocyte casts. Serum creatinine levels rose sharply. Corticosteroids, antihypertensives, and hemodialysis resulted in clinical improvement and fast kidney function recovery. Due to limited resources, no kidney biopsy was conducted. This case provides a diagnostic approach to RPGN in IgA nephropathy in resource-limited settings, along with comprehensive therapy.