Jurnal Insan Farmasi Indonesia
Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia

VALIDASI METODE PENETAPAN KADAR HIDROKUINON PADA PRODUK KRIM PEMUTIH DENGAN METODE SPEKTROFOTOMETRI-UV

Wahyuningsih, Putri Dewi (Unknown)
Kusumowati, Ika Trisharyanti Dian (Unknown)



Article Info

Publish Date
31 Dec 2024

Abstract

Whitening cream is a type of cosmetic product that contains organic chemicals or other substances that can lighten the skin. One of the additional chemicals found in whitening creams is hydroquinone. The mechanism of hydroquinone in lightening the skin involves inhibiting melanin production. According to BPOM Regulation No. 23 of 2019, hydroquinone is only allowed for use in artificial nail preparations at a maximum concentration of 0.02% after mixing before use. This study aims to identify the concentration of hydroquinone in whitening cream products available in the Madiun City area. Hydroquinone identification was conducted qualitatively using 5% FeCl3. The quantitative determination of hydroquinone concentration was performed using UV spectrophotometry. Based on the validation parameter calculations, the equation obtained is Y = 0.0463x - 0.0734, with linearity represented by a correlation coefficient (r) of 0.999, LOD of 0.549 ppm, and LOQ of 1.832 ppm, precision with %RSD of 0.9075%, and % recovery of 99.47%. From the test results, it was found that 4 out of 5 samples of whitening cream products contained hydroquinone, with sample B having a concentration of 1.31979%, sample C 1.05197%, sample D 0.89791%, and sample E 1.28956%.

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Journal Info

Abbrev

JIFI

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics

Description

Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that ...