Performance evaluation of Pharmacy Management Information System (PMIS) at Roemani Hospital was done because a policy of pharmacy system operation had not been fully implemented, a finance manager was difficult to predict expenditures to buy stock of medicines, information about amount of medicine on the pharmacy information system was different from amount of medicine which was available in repository, and quality of pharmacist was still low. Analysis model of HOT - Fit put important components on information system namely Human, Organization, and Technology. This research aimed to find out about performance of pharmacy information system at Muhammadiyah Roemani Hospital viewed from users’ perceptions using indicators of Hot Fit Model. This was descriptive research using quantitative approach. Population was all officers (40 persons) who were involved in PMIS. Research instruments consisted of a questionnaire, an observation sheet, and guidance interview. Furthermore, data were analyzed using descriptive statistics continued by categorizing to be good (e”mean/median) and bad (
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