Acta Biochimica Indonesiana
Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana

Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases

Aulanniam (Unknown)
Rudijanto, Achmad (Unknown)
Wijaya, Andreas Budi (Unknown)

Article Info

Publish Date
13 Oct 2024

Abstract

The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding TPO and TSHR as biomarkers over recent decades have enhanced their clinical application. This review explores the molecular basis of TPO and TSHR as biomarkers, highlighting their importance in diagnosing AITD and their potential to guide effective therapeutic strategies. Additionally, it discusses the development of lateral flow assay (LFA) kits developed by the authors, which show promise as rapid and reliable diagnostic tools for AITD.

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Journal Info
Acta Biochimica Indonesiana
Website

Abbrev

actabioina

Publisher

Perhimpunan Biokimia dan Biologi Molekuler Indonesia

Subject

Biochemistry, Genetics & Molecular Biology

Description

Acta Biochimica Indonesiana (ActaBiolna) is a peer-reviewed and open-access journal that disseminates original research articles and review articles covering diverse topics in Biochemistry and Molecular Biology. The journal is published biannually by Indonesian Society for Biochemistry and Molecular ...