<![CDATA[Bacterial bloodstream infection is a critical public health issue due to its high morbidity and mortality rates. Prompt diagnosis and appropriate treatment are essential for improving patient outcomes. This study aimed to identify the bacterial composition of bloodstream infections and their antibiotic resistance patterns at Medical City Hospital, Baghdad. A cross-sectional study of 462 fever-diagnosed individuals (244 females, 218 males) conducted from July 3 to September 24, 2024, found that 96 (20.8%) had culture-positive bacteria. Staphylococcus aureus (30.21%) was the most prevalent, followed by coagulase-negative staphylococci (26.04%), Escherichia coli (10.42%), Enterobacter cloacae (8.34%), Streptococcus pyogenes (7.29%), Citrobacter spp. (6.25%), and Klebsiella spp. (5.25%). Antibiotic resistance was high, particularly to oxacillin (95.63%), ampicillin (97.79%), and gentamicin (88.54%). Multidrug resistance was identified in 87.49% of bacterial isolates, with susceptibility to cefotaxime, azithromycin, ceftriaxone, and ciprofloxacin. Notably, Gram-positive bacteria showed significant resistance to vancomycin and oxacillin (54.17%). These findings underscore the importance of routine susceptibility testing for pathogens and antibiotics to prevent the spread of resistant bacterial infections and guide effective treatment strategies. Highlights: Identify bloodstream infection bacteria, analyze antibiotic resistance patterns. 20.8% culture-positive; Staphylococcus aureus most prevalent; high resistance. Multidrug resistance prevalent; emphasize susceptibility testing to manage resistance. Keywords: Bloodstream infections, Antimicrobial resistance, Multidrug, Cross-sectional research, Microbiological analysis]]>
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