<![CDATA[Aeromonas hydrophila is a pathogenic bacterium that often causes disease in freshwater fish, thus impacting food insecurity and global economic losses. Biofilm formation by A. hydrophila regulated by the quorum sensing (QS) system plays an important role in increasing virulence and resistance to antibiotics. Inhibiting the QS system can be an option to control A. hydrophila infection in fish. One of the ingredients that can be used is octopus ink extract containing alkaloids. This study aims to analyze the potential of octopus ink extract as an anti-quorum sensing agent in preventing the formation of A. hydrophila biofilms in aquaculture. The method used is a systematic literature study by collecting data from scientific articles. The analysis was carried out in depth to evaluate the mechanism of octopus ink extract in inhibiting QS and bacterial biofilms. The results showed that active compounds in octopus ink, such as alkaloids, can inhibit communication between bacterial cells by blocking QS autoinducers. This process suppresses the expression of virulence genes and prevents biofilm formation without affecting bacterial viability, so the risk of antibiotic resistance can be minimized. In conclusion, octopus ink extract has great potential as an anti-quorum sensing agent to support the management of A. hydrophila infection in aquaculture. The use of this extract is not only effective but also environmentally friendly, offering an innovative solution to improve the health of farmed fish and the sustainability of the aquaculture industry. Furthermore, octopus ink extract can be used as an immunostimulant in aquaculture industry.]]>
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