Indonesian Journal of Pharmaceutical Science and Technology
Vol 12, No 1 (2025)

The Optimization of Porang starch-lactose as a co-processed excipient of Bajakah (Spatholobus littoralis Hassk) root dried extract's effervescent tablet

Ermawati, Dian Eka (Unknown)
Andini, Bimar Putri (Unknown)
Damayanti, Avina Kusuma (Unknown)



Article Info

Publish Date
28 Feb 2025

Abstract

Bajakah root has stronger antioxidant activity than vitamin C. The Dayak people use it to maintain health. Bajakah root infusion has an unpleasant taste and aroma, also unstable, so effervescent tablets are developed to resolve that problem. Effervescent tablets are prepared by direct compression method. The starch of porang tuber is a food that can act as fillers and tablet binders. The co-processed excipient can produce tablet fillers for the directly compressed method. Co-processed excipients of lactose-porang starch have excellent flow properties, improve tablet hardness, have good compatibility, and are cheaper. In this study, the proportions of porang starch and lactose as co-processed excipients were determined using the Simplex Lattice Design method, and then tested the flow properties and granule repose angle. The physical properties of the tablets include weight uniformity, hardness, brittleness, dissolution time, and antioxidant activity test. Test data were analyzed using the One Sample T-test. The results showed that effervescent tablets with co-processed excipient porang starch-lactose 64: 36% provide good physical stability, granule flow time of 10.45 ± 0.29 gram/second, granule repose angle of 27.52 ± 0.95°; tablet weight uniformity with a CV value of 1.021%; tablet hardness 5.74 ± 0.07 Kg, tablet friability of 0.549 ± 0.03%; tablet disintegration time 86 ± 4 seconds. The bajakah root has antioxidant activity of 0.155 mg/mL.

Copyrights © 2025






Journal Info

Abbrev

ijpst

Publisher

Subject

Computer Science & IT Medicine & Pharmacology

Description

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan ...