CAUCHY: Jurnal Matematika Murni dan Aplikasi
Vol 10, No 1 (2025): CAUCHY: JURNAL MATEMATIKA MURNI DAN APLIKASI

Understanding The Mechanism of GLUT4 Translocation Involving Non-Conserved Complexes from A Modeling and Simulation T2DM Perspective

Kusumastuti, Ari (Unknown)
Irawan, Mohammad Isa (Unknown)
Fahim, Kistosil (Unknown)



Article Info

Publish Date
22 Mar 2025

Abstract

Understanding the mechanism of Glucose Transporter 4 (GLUT4) translocation to the cell membrane is essential for describing daily glucose uptake. A normal mechanism maintains glucose homeostasis and reduces the occurrence of Type 2 Diabetes Mellitus (T2DM) and its complications. Kinetic reactions are crucial for revealing the interactions involving proteins, enzymes, and complexes within the system. We propose a system of ordinary differential equations (ODEs) to elucidate the underlying mechanism under the assumption of non-conservative complexes . The insulin signaling pathway, which includes the GLUT4 mechanism, serves as the basis for reconstructing the necessary kinetic reactions. Investigating the behaviour of the model through numerical simulations and dynamics within parameters and initial conditions from relevant researchs .

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Journal Info

Abbrev

Math

Publisher

Subject

Mathematics

Description

Jurnal CAUCHY secara berkala terbit dua (2) kali dalam setahun. Redaksi menerima tulisan ilmiah hasil penelitian, kajian kepustakaan, analisis dan pemecahan permasalahan di bidang Matematika (Aljabar, Analisis, Statistika, Komputasi, dan Terapan). Naskah yang diterima akan dikilas (review) oleh ...