CHEMVIRO : Jurnal Kimia dan Ilmu Lingkungan
Vol. 1 No. 2 (2023): Vol. 1 No. 2 (2023)

Studi Doking Molekuler Perbandingan Evektivitas Senyawa Dari Buah Morinda Citrifolia L Sebagai Antikanker: Molecular Docking Studies of comparison the effectiveness compounds from Morinda citrifolia L. fruits as an anticancer

Rahman, Adiputra (Unknown)



Article Info

Publish Date
17 Aug 2023

Abstract

Cancer is a disease resulting from abnormal cell growth that leads to malignant neoplasms. Carcinoma Mammae (Ca Mammae) is a term for breast cancer which is characterized by the growth of malignant tumors in the breast tissue. Breast cancer is the main killer of women in the world, this is because every year there have been more than 1,000,000 cases in the world. Treatment of breast cancer is generally carried out through surgery which, if necessary, chemotherapy or radiation is a follow-up treatment. Therefore, early treatment with a variety of medicinal plants is an additional hope for controlling this breast cancer so that it can finally recover completely. The potentially medicinal compounds contained in noni fruit (Morinda citrifolia L.) include anthraquinones and quercetin, which play a role in inhibiting the development of cancer cells. This study aims to compare the potential of anthraquinones and quercetin from Morinda citrifolia L. fruit in preventing and treating cancer with Doxorubicin as a control. This step consists of target ligand and protein preparation, molecular docking, and drug similarity testing based on the Lipinski rule. The results showed that the anthraquinone compound from Morinda citrifolia L. fruit had better and safer anticancer potential with the lowest binding affinity -7.5.

Copyrights © 2023






Journal Info

Abbrev

CHEMVIRO

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science

Description

CHEMVIRO : Jurnal Kimia dan Ilmu Lingkungan (JKIL) dengan nomor registrasi ISSN :2986-5255 (online), merupakan jurnal ilmiah yang menerbitkan artikel-artikel yang berkaitan dengan pendidikan Kimia dan Ilmu Lingkungan. Jurnal ini akan menerbitkan dua isu dalam setahun (Februari dan Agustus). Setiap ...