PENGARUH PEMBERIAN EKSTRAK ETANOL RIMPANG LENGKUAS (ALPINIA GALANGA) TERHADAP GAMBARAN HISTOPATOLOGI OTAK MENCIT (MUS MUSCULUS L) YANG DIINDUKSI MONOSODIUM GLUTAMATE

Emeraldha Theodorus (Fakultas Kedokteran, Universitas Lampung)
Muhartono Muhartono (Bagian Patologi Anatomi, Fakultas Kedokteran, Universitas Lampung)
Giska Tri Putri (Bagian Biokimia, Fakultas Kedokteran, Universitas Lampung)

JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Vol 7 No 2 (2019): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 7.2 Edisi Mei - Oktob

Abstract Background: Monosodium glutamate (MSG) induced brain damage characterized by microscopic neuronal necrosis and clinically neurologic deficits. Galangal has flavonoid that serves as an antioxidant that can protect the brain. Objective: To determine the effect of ethanol extract of galangal rhizome (Alpinia galanga) on brain histopathological appearance in the mice (Mus musculus L) induced by Monosodium glutamate (MSG). Methods: This study used 30 mice that were divided into 5 groups. K(-) is not given any treatment, K(+) is given intraperitoneal MSG 4 mg/grBB, P1 is given intraperitoneal MSG 4 mg/grBB and oral galangal extract 14 mg/ 20grBB, P2 is given intraperitoneal MSG 4 mg/grBB and oral galangal extract 28 mg/ 20grBB, and P3 P1 is given intraperitoneal MSG 4 mg/grBB and oral galangal extract 56 mg/ 20grBB. Results: The average number of brain neuronal necrosis were K(-) 3,8; K(+) 5,4; P1 5,4; P2 5; dan P3 4,8. The One-Way ANOVA result showed that the p-value =……. 0,015. Conclusion: There are no difference in the effect of ethanol extract of galangal rhizome (Alpinia galanga) on brain histopathological appearance in the mice (Mus musculus L) induced by Monosodium glutamate (MSG).