<![CDATA[Introduction: Ovarian cancer has a major role as the causes of prevalence and deathsworldwide and has been estimated at 2025 they will rise over heart disease as the largestcause of death. Indonesia is one of the developing countries that have the death ratefrom ovarian cancer is the third-highest in Asia after China and India. The prevalence of ovarian cancer could be suppressed if the detection and early diagnosis can beestablished. However, detection of which is currently used is CA125 is still inadequate asa diagnosis of early-stage ovarian cancer because this biomarker has high sensitivity andspecificity only at an advanced stage which is the stage is already quite late to be treated.Discussion: The overexpression WFDC in vitro and in vivo indicate a significantcontribution to the proliferation, cell growth rate, invasive capability, and independentgrowth in tumor cells. Additionally, WFDC2 has a higher sensitivity and specificity inearly-stage cancer (stage 1 and 2) compared to CA125 and combination ofCA125+WFDC2 so it is very advantageous for clinician to detect ovarian cancer earlier.Conclusion: WFDC2 can be used as a biomarker for the detection and early diagnosis ofovarian cancer.]]>
Copyrights © 2018
