This study aims to identify the effect of health education on the knowledge and attitude of brides and grooms in the community health center of Duri Pulo Village Gambir Sub-District. This was a quasi-experimental study with one-group pre-posttest design. The results showed that the mean values of pretest and posttest were 1.75 and 3.05, respectively, showing 1.3 difference between the two. The p value was 0.00, meaning that the p value <0.05, hence, Ho was rejected. There was an effect of health education on the knowledge and attitude of brides and grooms. For the health center in question, the researcher is expected to hold a health outreach or education on the knowledge and attitude of brides and grooms
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