<![CDATA[Orthodontic pressure applied to the teeth causes stress and inflammation in the periodontal tissues. Channa striata extract gel and hyperbaric oxygen therapy (HBOT) accelerate the healing process of periodontal tissues under stress due to orthodontic pressure by stimulating osteoblasts to form bone trabeculae in tension areas on bone remodeling. To determine the effect of the combination of Channa striata extract gel and HBOT on the trabecular bone area during orthodontic tooth movement in the tension area. 30 male Cavia cobaya were randomly divided into 5 groups (n=6): negative control (K-) without orthodontic tooth movement (OTM), positive control (K+) with OTM, treatment (P1) with OTM and Channa striata extract gel, treatment (P2) with OTM and HBOT, and treatment (P3) with OTM and combination of Channa striata gel extract and HBOT. Rubber separators were attached to the maxillary central incisors. HBOT 2.4 ATA was administered for 7 days from day 17 to day 23, and Channa striata gel was administered for 14 days from day 10 to day 23. The trabecular bone area was examined using HE staining, and results were calculated using Image Raster. Data were evaluated using the One-Way ANOVA test and LSD (p<0.05). The mean trabecular bone area was the largest in the P3 group (1,126,649.83+90,817.17). Anova and LSD analysis showed that the most significant difference was found in group P2 (p<0.05). The combination of HBOT and Channa striata gel extract affects the trabecular bone area in the tension area during OTM, and the most effective therapy is HBOT]]>
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