Cermin Dunia Kedokteran
Vol 50 No 3 (2023): Kardiologi

Carvedilol untuk Tata Laksana Clinically Significant Portal Hypertension pada Sirosis Kompensata

Achmad Faiz Sulaiman (Achmad Faiz Sulaiman Dokter Umum Klinik Utama Muhammadiyah Asy-Syifa Kudus, Indonesia)



Article Info

Publish Date
01 Mar 2023

Abstract

Hipertensi portal merupakan konsekuensi klinis dari sirosis hati. Angka kematian karena hipertensi portal masih tinggi di Indonesia. Pada kondisi sirosis kompensata munculnya hipertensi portal yang signifikan secara klinis (clinically significant portal hypertension/CSPH) dapat memprediksi kejadian dekompensasi dan merupakan penanda prognosis penyakit yang lebih buruk. Diagnosis CSPH dapat dengan cara invasif ataupun non-invasif. Tata laksana CSPH pada kondisi sirosis kompensata diutamakan untuk mencegah timbulnya dekompensasi sirosis. Pemberian penghambat beta non-selektif (non-selective beta blocker/NSBB) pada kondisi sirosis kompensata efektif menurunkan hipertensi portal dan mampu mencegah dekompensasi. Portal hypertension is a major consequences of liver cirrhosis. Mortality rate from portal hypertension is quite high in Indonesia. In patients with liver cirrhosis, the development of clinically significant portal hypertension (CSPH) is predictive for decompensation and worse prognosis. Diagnosis of CSPH can be carried out by either invasive or non-invasive methods. The aim of CSPH management in compensated cirrhosis is to prevent the incidence of decompensation. Management of compensated cirrhosis with non-selective beta blocker (NSBB) has been shown to reduce portal hypertension and the incidence of first decompensation.

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Journal Info

Abbrev

cdk

Publisher

Subject

Health Professions

Description

Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK ...