Tata Laksana Lambert Eaton Myasthenic Syndrome

Marcellinus Michael Leonard Mardiono (RS Gading Pluit)
Widyawati Suhendro

Cermin Dunia Kedokteran
Vol 50 No 11 (2023): Pediatri

Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular junction disorder resulting from a paraneoplastic or autoimmune reaction. More than half LEMS cases are associated with small cell lung carcinoma (SCLC). The main clinical manifestation is muscle weakness. The pathophysiology is due to the generation of the autoantibodies against voltage-gated calcium channels (VGCCs) on presynaptic nerve terminals leading to a decrease in neurotransmitter acethylcholine (ACh). Various treatments such as tumor treatments, immunomodulatory, and symptomatic treatment have been studied, but further research is needed.