Cermin Dunia Kedokteran
Vol 45 No 4 (2018): Neurologi

Tren Terapi Diabetes dengan GLP-1 Receptor Agonist

Pande Made S. Dharma Pathni (Medical Department, PT Kalbe Farma Tbk., Jakarta, Indonesia)

Article Info

Publish Date
02 Apr 2018

Abstract

GLP-1 menjadi target terapi DM tipe 2. Analog GLP-1 memiliki aktivitas serupa GLP-1 endogen, namun dengan kelebihan resisten terhadap deaktivasi enzim DPP-4, menghasilkan aktivitas yang lebih panjang. Manfaat lain obat golongan ini adalah menurunkan kadar hormon glukagon, memperlambat pengosongan lambung, dan menginduksi rasa kenyang.   GLP-1 becomes a therapeutic target of type 2 DM. Analogue of GLP-1 has the activity that mimics endogenous GLP-1, with advantages to be resistant to DPP-4 enzyme deactivation, resulting in longer activity. Other activities of this class are to lower glucagon hormone level, slow gastric emptying and induce satiety.

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Journal Info
Cermin Dunia Kedokteran
Website

Abbrev

cdk

Publisher

PT. Kalbe Farma Tbk.

Subject

Health Professions

Description

Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK ...