There is evidence that termite colonies of the subfamily Termitomyces produce an unusual structure called a fungus comb, especially Termite mounds in Indo-Malaysian regions. This comb may include bioactive components that the termites use to investigate if they might aid in the body's inflammatory response. The anti-inflammatory potential, concentration, and bioavailability of fungal comb from the Indo-Malayan termite macrotermes gilvus Hagen mound will be further discussed in this research. We utilized databases to review the current evidence related to anti-inflammatory potential of fungus combs and termite macrotermes gilvus hagen mound. We discussed the most recent evidence of fungus combs and termite macrotermes gilvus mound regarding the anti-inflammatory potential, concentration, and bioavailability. This study concludes that ethyl acetate extract from fungus comb could enhance the immune system. Phenolic compounds have a positive effect on health indicators. These mechanisms may account for the decreased prevalence of chronic degenerative disorders in populations.
                        
                        
                        
                        
                            
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