The sale of prescription drugs without a doctor's prescription remains a common issue in many pharmacies, despite clear regulations prohibiting such practices. This article is a narrative literature review aimed at analyzing the legal framework, pharmacist accountability, and the effectiveness of supervision concerning the distribution of prescription-only medicines in Indonesia. The review is based on five relevant scientific articles and a selection of applicable legal regulations. Findings show that regulatory loopholes, weak enforcement of administrative sanctions, and low public awareness regarding appropriate drug use contribute to ongoing violations. Furthermore, the rise of online pharmacies and the ease of accessing drugs through digital platforms exacerbates the risk of misuse. Therefore, it is essential to strengthen adaptable regulatory frameworks, enhance public education, and develop an integrated supervision system, including the use of digital verification technologies.
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