Based on World Health Organization (WHO) the cases of death due to Chronic Kidney Disease (CKD) ranked the 10th worldwide in 2020. CKD need to be done prevent early. History data to identify individuals predisposed to CKD in this research. In this research data contains missing values, therefore using Fuzzy C - Means (FCM) method to address it. The percentage of error in clustering CKD using FCM method is 20,25% and balanced accuracy of 84,80%. The result from classification using Classification and Regression Trees (CART) shows that accuracy value of 97,50%; sensitivity of 100,00%; and specificity of 92,86%. Individual suffer from CKD if having (1) hemoglobin more than or equal 13; spesific gravity 1,020 or 1,025; serum creatinine less than 1,3; albumin 1 or 2 or 3 or 4 or 5; and sugar 0 or 2 or 3 or 4 or 5, (2) hemoglobin more than or equal 13; spesific gravity 1,020 or 1,025; and serum creatinine more than or equal 1,3, (3) hemoglobin more than or equal 13 and spesific gravity 1,005 or 1,010 or 1,015, (4) hemoglobin less than 13 and red blood cell count less than 5,5.
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