<![CDATA[One of the human infections caused by bacteria is digestive tract infection, some of these bacteria include S.typhi, E.coli, S.dysenteriae. Antibiotics are required to treat infectious diseases caused by microbes; however, most antibiotics cause resistance to these microbes. To avoid this, researchers are interested in developing plant-derived antibiotics. This review aims to evaluate the antibacterial effectiveness of ZnO nanoparticles synthesized from plant extracts or microorganisms and their antibacterial activity against gram-positive bacteria (B. Cereus & S. Aureus) and gram-negative bacteria (E. Coli, K. Pneumonia & S. Thypi). From this review, it can be concluded that ZnO nanoparticles have significant antibacterial activity against gram-negative bacteria. This antibacterial effectiveness is influenced by the particle size, ZnO-NPs concentration, and environmental conditions, such as pH and temperature. However, further studies are needed to determine the effectiveness of biosynthesized ZnO nanoparticles and their activities other than antibacterials. Keywords: Zinc Oxide Nanoparticles, Nanoparticles, Antibacterial, Biosynthesis, Green Synthesi ]]>
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