Bacground: Stress has been already known affecting hormonal axis. However, the association between stress and menopause is poorly understood. The study was aimed to determine the association between stress at work and the onset of menopause of the women teachers in Senior High Schools in Surakarta. Methods: This was an observational cross-sectional research using cross sectional design. The sample was active women teachers who were regularly  teaching in Senior High Schools at Suraâkarta who already had menstrual periods stop. Sampling was done using a simple random sampling method with amount of sample 58 women teachers. The data of stress at work were obtained by International Stress Management Assosiation (ISMA) quistionare and the onset of menopause were obtained by interviews. The data were analyzed with unpaired t-test and Spearman correlation test. Results: Stress at work was significantly correlated with the onset of menopause (r = -0.441; p = 0.009). Stress at work was found to be significantly associated with onset of menopause (p < 0.05). Conclusion: This research shows a significant correlation between work stress and the onset of menopause with negative direction and moderate strength. Keywords: menopause, stress at work
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