Science and Technology Indonesia
Vol. 10 No. 4 (2025): October

Synthesis, Characterization, Anticancer, and Molecular Docking Investigations of Benzothiazole Metal Complexes

Periyasamy, Kavitha (Unknown)
Nainamalai, Vijayakumari (Unknown)

Article Info

Publish Date
01 Oct 2025

Abstract

The synthesized 2-aminobenzothiazoles based ligand reacted with various transition metal salts were smoothly converted to square planner complexes. The synthesized transition metal complexes are analyzed by using various characterization techniques. Anticancer activity of Schiff base ligand and synthesized metal complexes are examined against human prostate cancer cell line (DU145) MTTassay at different concentration (1, 2, 4, 8, 16, 32, 64, 128, 256, and 512 ug/mL). The IC50 values of metal complexes and free ligand were 16.21 (SBI-Co), 75.98 (SBI-Ni), 25.53 (SBI-Cu), 81.71 (SBI-Zn), and 29.6 (free ligand) ug/mL respectively. Cohasmorepotent against human prostate cancer cell line (DU145). In contrast, the molecular docking study shows, Cu (II) complex has significant inhibition against human 2W3L protein.

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Journal Info
Science and Technology Indonesia
Website

Abbrev

JSTI

Publisher

Universitas Sriwijaya

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

Description

An international Peer-review journal in the field of science and technology published by The Indonesian Science and Technology Society. Science and Technology Indonesia is a member of Crossref with DOI prefix number: 10.26554/sti. Science and Technology Indonesia publishes quarterly (January, April, ...