<![CDATA[Meta-analysis is a statistical method for synthesizing quantitative data from multiple related studies, yet heterogeneity among studies often complicates interpretation. Meta-regression extends this approach by incorporating study-level covariates to explain variations in outcomes. With the global increase in depression, Acceptance and Commitment Therapy(ACT) has attracted attention as an effective psychological intervention. Therefore, a deeper understanding of the factors that influence its effectiveness across studies is needed. However, to date, only a few meta-analyses have quantitatively examined moderator variables that influence ACT outcomes using a random effects meta-regression approach. This study aims to fill this gap. This study estimated the model parameters using the Weighted Least Squares (WLS) method. Thirty-three published studies testing the effectiveness of ACT in reducing depression were collected from PubMed, Google Scholar, and Science Direct. The homogeneity test results showed significant heterogeneity, supporting the use of a random effects model. The combined effect size of -0.321 indicates that ACT significantly reduces depression levels compared to the control group. Meta-regression analysis revealed that variation in effect size was significantly influenced by differences in the average age of patients and duration of therapy. These findings provide new insights into the conditions and characteristics that make ACT therapy more effective.]]>
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