Buletin Farmatera
Vol 11, No 1 (2026)

HbA1c Levels Relate to the Severity of Atherosclerotic Lesions in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus

Faridah Zulfa Rambe (Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara)
Sheila Dhiene Putri (Department of Cardiology, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara)



Article Info

Publish Date
01 Feb 2026

Abstract

Abstract: Cardiovascular disease is one of the main causes of death in the world. In diabetes mellitus patients who experience hyperglycemia, the risk of coronary heart disease increases 2-4 times. Diabetes mellitus can be diagnosed using HbA1c examination. Coronary heart disease can be diagnosed using a coronary angiography examination, and the results are assessed using the vessel disease score. The design of this research is observational analytic with a cross-sectional approach. The research was conducted in October-December 2023 at RSU. Medan Hajj. The sample for this study was patients with coronary heart disease who had type 2 diabetes mellitus and underwent HbA1c examination and coronary angiography. Data analysis used the Mann-Whitney test. Based on data from RSU. Haji Medan obtained 23 samples, after 18 samples of multi-vessel disease were found with uncontrolled HbA1c levels, and then analysed with a result of 0.027 (p-value 0.05), which means there is a relationship between HbA1c levels and the severity of atherosclerotic lesions in disease patients. Coronary heart disease patients who have type 2 diabetes mellitus. There is a relationship between HbA1c levels and the severity of atherosclerotic lesions in coronary heart disease patients who have type 2 diabetes mellitus.

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