Vaccination have an important role in COVID-19 management, however clinicians should monitor its adverse effects. A young female was admitted to the emergency room with a severe anemia, shortness of breath and profound jaundice which was then diagnosed as autoimmune hemolytic anemia. Three days prior to the admission, she had her first dose of mRNA-based COVID-19 vaccine. After steroid administration and erythrocyte transfusion, her condition was better and her hemoglobin level was back to normal. An autoimmune condition triggered by vaccination should be closely monitored.
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