<![CDATA[Tuberculosis (TB) remains a major public health issue in Indonesia. Treatment adherence among TB patients is essential and influenced not only by medical conditions but also psychological, social, and environmental factors. This study aimed to identify factors affecting treatment adherence in TB patients at Dr. Yos Sudarso Hospital, Padang. A quantitative, cross-sectional design was used, involving 50 purposively selected patients. Data were collected through structured questionnaires covering demographics, TB knowledge, family support, patient-health worker relationships, drug side effects, and medication adherence levels. Bivariate and multivariate analyses were conducted to determine significant influencing factors. Results showed that most respondents (60%) were aged 26–45 years, had secondary education, and 70% adhered to treatment. Multivariate analysis revealed that good patient knowledge about TB (OR = 4.10; p = 0.018) and strong family support (OR = 3.25; p = 0.032) were significantly associated with better adherence. Drug side effects were noted as a key barrier to consistent medication use. In conclusion, TB treatment adherence at Dr. Yos Sudarso Hospital is shaped not only by individual patient factors but also by family support, treatment experiences, and interactions with healthcare providers. Improving adherence requires continuous, tailored education based on patient literacy levels, involving families as treatment companions, and effectively managing side effects.]]>
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