Jurnal Sains Farmasi dan Kesehatan
Vol. 3 No. 2 (2025): September - Desember

Artikel Review Fitokimia : Efektivitas Refluks Sebagai Metode Ekstraksi

Nungki Hatit Isafani (S1 Farmasi, Fakultas Ilmu Kesehatan Universitas Anwar Medika, Sidoarjo)
Nailah Mutiara Wahid (S1 Farmasi, Fakultas Ilmu Kesehatan Universitas Anwar Medika, Sidoarjo)
Marscha Dwi Lestari (Universitas Anwar Medika, Sidoarjo)
Ryan Satria Pranata (Universitas Anwar Medika, Sidoarjo)
Meiva Shafa Herdini (Universitas Anwar Medika, Sidoarjo)
M. Ilham Fannany (Universitas Anwar Medika, Sidoarjo)
Helmalia Jelita Putri (Universitas Anwar Medika, Sidoarjo)
Anisa Rachman (Universitas Anwar Medika, Sidoarjo)
Nadya Tazkiyah Tsabitah (Universitas Anwar Medika, Sidoarjo)
A’Yunil Hisbiyah (Universitas Anwar Medika, Sidoarjo)
Ivan Charles S.Klau (Universitas Anwar Medika, Sidoarjo)
Arista Wahyu Ningsih (Universitas Anwar Medika, Sidoarjo)



Article Info

Publish Date
12 Nov 2025

Abstract

The reflux extraction method is a technique that uses a solvent at its boiling point for a certain time with a stable solvent volume, due to the presence of a reflux condenser. This method is generally used to extract coarse-textured and heat-resistant materials, because the process involves continuous heating. The main advantage of the reflux method is its ability to efficiently extract samples with coarse textures. This article discusses the effectiveness of reflux extraction by outlining its working principle, factors that influence extraction results, its advantages and disadvantages, applications to various phytochemical compounds, and also innovative developments of this method. In the reflux method, the solvent is heated to its boiling point and the solvent vapor formed is recondensed so that it can circulate repeatedly. This process allows for more efficient and stable extraction. Several factors that influence extraction results include the type of solvent, temperature, stirring speed, solvent, the ratio between the material and the surface area of ​​the material, and the length of the extraction time. Sari's research results showed that the galactomannan yield from coconut pulp using aquadest solvent reached 3.82%, higher than Zultiniar's research using methanol with a yield of 0.90%. This result is consistent with the research of Zulmi et al. who extracted galactomannan from palm fruit using aquadest solvent, while Tarigan who used ethanol obtained a lower yield.

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Journal Info

Abbrev

jfkes

Publisher

Subject

Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

Description

Jurnal Sains Farmasi dan Kesehatan (JFKES) E-ISSN : 3024-9368 is an open access journal which is a media of research publication and review article on all aspects of pharmaceutical science that is innovative, creative, original and based on scientific. Articles published in this journal include ...