Background: Ventricular septal defect (VSD) is the most common congenital heart defect in neonates. Its association with congenital syphilis is rarely reported, although transplacental infection by Treponema pallidum can cause multisystem involvement.Objective: To report a case of VSD in a neonate with congenital syphilis and to document relevant clinical and diagnostic findings.Methods: A descriptive case report was conducted on a 14-day-old female neonate delivered via cesarean section to a mother with reactive syphilis and gestational hypertension. Congenital syphilis was confirmed by VDRL and TPHA serological testing. Clinical evaluation and echocardiography were performed to assess cardiac anomalies.Results: Echocardiography revealed a 7,6 mm VSD with bidirectional shunt involving the inlet, muscular, and subaortic regions. These findings provide a detailed description of structural heart involvement in a neonate with congenital syphilis, although a direct causal relationship cannot be established.Conclusion: This case highlights the importance of early maternal syphilis screening and neonatal cardiac evaluation. The report serves as preliminary documentation for monitoring potential cardiac anomalies in neonates with congenital syphilis and encourages further investigation into possible clinical associations.
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