Media Gizi Kesmas
Vol 14 No 2 (2025): MEDIA GIZI KESMAS (DECEMBER 2025)

The Role of Phenolic Compounds in Antioxidant Enhancement in Obese Individuals: A Systematic Literature Review

Maulani, Sifa (Unknown)
Farapti, Farapti (Unknown)



Article Info

Publish Date
27 Nov 2025

Abstract

Background: Chronic inflammation and oxidative stress are complications of obesity. Consuming phenolic compounds found in plant-based foods can reduce inflammation and oxidative stress. Phenolic compounds are phytochemicals with antioxidant properties that play an important role in health. Objectives: This article aims to examine the role of phenolic compounds in obese individuals. Methods: This article uses a literature review method with predetermined inclusion and exclusion criteria. Articles were searched for in several electronic databases, namely PubMed and Wiley Online Library. Results: Phenolic compounds can reduce inflammation and oxidative stress through several mechanisms. One of these is that fermented flaxseed extract improves neural health and reduces obesity markers in experimental models. Polyphenolic compounds from pigmented rice effectively reduced lipid peroxidation and pro-inflammatory cytokines. The findings highlight the anti-adipogenic, anti-inflammatory, and metabolic regulation properties of phenolic compounds. Conclusion: Phenolic compounds play an important role in reducing oxidative stress and inflammation in obesity. Their effectiveness varies depending on the source of the compounds, with promising results from pigmented rice, fermented black beans, and fermented flaxseed. However, most results are from in vitro or animal studies, so further clinical trials are needed to validate these benefits in humans.

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Journal Info

Abbrev

MGK

Publisher

Subject

Environmental Science Health Professions Nursing Public Health Social Sciences

Description

Media Gizi Kesmas (MGK) is a scientific journal under the auspices of Universitas Airlangga that uses a peer review system and is published by the Faculty of Public Health, Universitas Airlangga. It is published twice a year, in June and December. Articles published in MGK include original research ...