In many countries, including Indonesia, liver disease remains a major cause of morbidity and mortality. Early detection plays a crucial role in improving treatment outcomes. This study evaluates the performance of two widely used machine learning models Random Forest and XGBoost for predicting liver disease, employing the SMOTE balancing technique to address class imbalance. The primary objectives are to enhance model fairness, reduce overfitting, and improve sensitivity toward the minority class. Model performance is assessed using accuracy, precision, recall, and F1-score metrics. The XGBoost model achieved an average accuracy of 99.74%, precision of 99.77%, recall of 99.75%, and F1-score of 99.72%, while the Random Forest model attained an average accuracy of 99.82%, precision of 99.89%, recall of 99.75%, and F1-score of 99.75%. Both models demonstrated excellent predictive capability, with Random Forest slightly outperforming XGBoost. These results highlight the importance of data balancing and robust model validation in developing reliable machine learning models for healthcare decision-making.
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