The difference of PGE2 and COX-2 expressions in various histological grading of endometrial endometrioid carcinoma

Yusfita Evi Rosdiana (Department of Anatomic Pathology, Faculty of Medicine, Universitas Airlangga)
Willy Sandhika (Department of Anatomic Pathology, Faculty of Medicine, Universitas Airlangga)

Majalah Obstetri dan Ginekologi
Vol. 25 No. 1 (2017): April

Objectives: to analyze the expression of PGE2 and COX-2 in various histological grade of endometrial endometrioid carcinoma.Materials and Methods: Analytical observational study was performed on parafin block archives of endometrial endometrioid carcinoma with histological grade 1,2 and 3 in Anatomic Pathology laboratory Dr. Soetomo hospital. PGE2 and COX-2 expression were examined by immunohistochemical staining using PGE2 and COX-2 antibodies. The results were analyzed statistically.Results: There were increase of PGE2 expressions of in endometrioid carcinoma grade 2 compare to  grade 1 and grade 3 compare to grade 2. The COX-2 expression was increase in histologic grade 3 compare to grade 1.Conclusion: The expression of PGE2 and COX-2 in endometrial endometrioid carcinoma were increased in higher histologic grade compare to lower histologic grade.