<![CDATA[Cosmos caudatus Kunth, a tropical medicinal herb traditionally used across Southeast Asia, has emerged as a promising botanical ingredient for cosmeceutical applications. This narrative review systematically synthesizes current evidence on its dermatological properties through comprehensive literature search of Scopus and PubMed databases (2015-2025), yielding 25 studies meeting inclusion criteria for skin-relevant bioactivities. Phytochemical characterization consistently identifies flavonoid glycosides, particularly quercetin derivatives (quercitrin, isoquercitrin, rutin), as major bioactive constituents responsible for multifaceted skin benefits. In vitro studies demonstrate potent antioxidant activity (IC₅₀ 17.77-163.6 μg/mL in DPPH assay), significant inhibition of collagenase, elastase, and matrix metalloproteinases underlying anti-aging effects, and superior tyrosinase inhibition (IC₅₀ 6.803 μg/mL) for skin brightening. Photoprotective capacity exhibits remarkable formulation-dependent enhancement, progressing from minimal protection in raw extracts (SPF 3.26) to ultra-protection in optimized cream formulations (SPF 45.59). Advanced delivery systems including nanotechnology (particle size 160-176 nm) and microencapsulation (79.67% flavonoid retention) further enhance stability and bioavailability. Additional antimicrobial activity against Propionibacterium acnes positions C. caudatus uniquely for acne-hyperpigmentation management. Despite robust in vitro evidence, clinical validation through human trials remains a critical research priority. This review establishes C. caudatus as a scientifically validated, multifunctional botanical ingredient with substantial commercial potential in the natural cosmeceutical market.]]>
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