Jurnal Biologi Tropis
Vol. 25 No. 4a (2025): Special Issue

A Novel Case of Reccurrent Hemarthrosis in a Patient with Undiagnosed Hemophilia

Ramadhita, Nova (Unknown)
Kurniawan, Yudhi (Unknown)



Article Info

Publish Date
31 Dec 2025

Abstract

Hemophilia is an inherited X-linked recessive bleeding disorder characterized by deficiency of coagulation factors and commonly presents with hemarthrosis that may lead to permanent joint damage if diagnosis is delayed. This report aims to describe a case of recurrent hemarthrosis that led to the diagnosis of previously unrecognized hemophilia B. We report a 3-year-old boy with progressive swelling and pain of the left knee following minor trauma and surgical intervention, with a history of easy bruising and prolonged bleeding after circumcision. Laboratory evaluation showed prolonged activated partial thromboplastin time with normal prothrombin time and platelet count, and coagulation factor assay revealed factor IX activity of 1.2%, consistent with moderate hemophilia B. Recurrent hemarthrosis in this patient was the key clinical manifestation that prompted further diagnostic evaluation. This case highlights that recurrent or persistent joint bleeding in children, especially in the absence of a clear family history, should raise strong suspicion of hemophilia. Early recognition through careful bleeding history, coagulation screening, and specific factor assays is essential to prevent long-term musculoskeletal complications and unnecessary surgical procedures.

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Journal Info

Abbrev

JBT

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

Description

Jurnal Biologi Tropis (ISSN Cetak 1411-9587 dan ISSN Online 2549-7863) diterbitkan mulai tahun 2000 dengan frekuensi 2 kali setahun oleh Program Studi Pendidikan Biologi PMIPA FKIP Universitas Mataram, berisi hasil penelitian dan ulasan Ilmiah dalam bidang Biologi ...