JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Vol. 4 No. 3 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)

In Vitro Effectiveness Test of Anti Acne Gel Formula in Combination With Natural Ingredients

WADHI, MARIA NUARI PUTRI (Unknown)
Bire, Winioliski Rohi (Unknown)
Kristiyanti, Yulia (Unknown)
Oeleu, Krisantus Yosef (Unknown)



Article Info

Publish Date
06 Jan 2026

Abstract

he development of this research aims to evaluate the antibacterial potential and formulation of Kaempferia galanga L. and Alpinia galanga L., which are plants containing ethyl para-methoxy cinnamate, flavonoids, polyphenols, and essential oils with potential antibacterial activity. The purpose of this study is to produce a stable gel formulation and determine its effectiveness. The simplicia was extracted using the maceration method with 70% ethanol as the solvent. The antibacterial activity of the extract was tested using the agar diffusion method at a concentration of 10%, followed by gel formulation with varying concentrations of the gelling agent, after which its effectiveness was assessed. The activity test results showed an inhibition zone of 9.63 mm for kencur and 10.3 mm for galangal, while the combination extract produced an inhibition zone of 12.14 mm. A stable formula was obtained at a concentration of 1.5% Carbopol 940 with an inhibitory effectiveness of 11.62 mm (Kaempferia galanga L. : Alpinia galanga L. ratio = 3 : 1), which is classified as having strong antibacterial activity.

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Journal Info

Abbrev

jakasakti

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Medicine & Pharmacology Public Health

Description

Journal on Health, Science, and Technology (JAKASAKTI) is an national journal published by the Research and Community Service Institute of Universitas Dhyana Pura, Bali. The Journal of Jakasakti is an open access and peer-reviewed journal, which is a dissemination medium for research result from ...