Advances in Cancer Science
Vol. 2 No. 3 (2025): October

The Effect of Radiation Dose on the Number of Leukocytes, Erythrocytes, and Thrombocytes in Cervical Cancer Patients Before and After Radiotherapy

Artitin, Cicillia (Unknown)
Nurmayana (Unknown)



Article Info

Publish Date
30 Oct 2025

Abstract

This study aims to determine the effect of radiation on the number of leukocytes, erythrocytes, and thrombocytes in cervical cancer patients before and after radiotherapy. This study was conducted at the radiotherapy facility of Arifin Achmad Regional General Hospital in Pekanbaru using a quantitative research method with a retrospective approach and secondary data from the medical records of 18 stage IIB–IIIB cervical cancer patients who underwent total radiotherapy of 50 Gy in 25 fractions. Data analysis was performed using the paired sample t-test and Wilcoxon signed rank test. The results showed a decrease in the mean leukocyte count from 10,18×10³/µL to 6,81×10³/µL, erythrocyte count from 3,92×10⁶/µL to 3,55×10⁶/µL, and platelet count from 253,72×10³/ µL to 181,39×10³/µL. Statistical tests showed a significant difference (p<0.05) between before and after radiotherapy. It was concluded that linac radiation had a significant effect on the decrease in the number of leukocytes, erythrocytes, and platelets in cervical cancer patients, so routine blood monitoring during therapy was necessary to prevent hematological complications.

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Journal Info

Abbrev

acsc

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology

Description

Advances in Cancer Science aims to publish research articles, reviews, and original studies that contribute to the understanding, diagnosis, treatment, and prevention of cancer. The focus of the journal encompasses various aspects of cancer biology, oncology, and related interdisciplinary fields. ...