Jurnal Kesehatan dr. Soebandi
Vol 13 No 2 (2025): Vol. 13 No. 2 (2025): Jurnal Kesehatan dr. Soebandi

Telang Flower Infusion Reduces Inflammation and Increases Goblet Cells in Infection Salmonella typhimurium Models

Destiawan, Rian Anggia (Unknown)
Delvia Asista Indarusanti (Unknown)
Ahdiah Imroatul Muflihah (Unknown)
Anas Fadli Wijaya (Unknown)



Article Info

Publish Date
31 Oct 2025

Abstract

Typhoid fever is an infectious disease caused by Salmonella Sp. This infection leads to a rise in inflammatory cells and a reduction in goblet cells, which are essential for protecting the intestinal lining. An alternative treatment option is the use of telang flower infusion, as its antioxidant content and active compounds show potential as anti-inflammatory agents. The purpose of this study was determining the effect of telang flower infusa on reducing inflammatory cells and increasing goblet cells in mice infected with S. typhimurium. This research design used the complete Randomized Design Method (RAL). The population of this study used mice (Mus musculus) which were divided into 6 groups: negative (without treatment), positive (only infected), stimuno (given a dose of 0.25 ml/20 g BB), treatment 1 (given telang flower infusa dose 0.25 ml/20 g BB), treatment 2 (given telang flower infusa dose 0.5 ml/20 g BB), and treatment 3 (given telang flower infusa dose 1 ml/20 g BB). Then, followed by necropsy, tissue processing, histology observation, and data analysis using Kruskal Wallis. Based on data analysis using normality and homogeneity test, the sig value was <0.05. So, the data is non-normal and not homogeneous. Meanwhile, in the Kruskal Wallis test, the sig value was 0.288 > 0.05, which means that there is no effect of swallowed flower infusion. There is no effect of telang flower infusa on reducing inflammatory cells and increasing goblet cells. Biologically, telang flower infusion can reduce inflammatory cells and increase goblet cells in mice infected with Salmonella typhimurium infection

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Journal Info

Abbrev

jkds

Publisher

Subject

Health Professions Medicine & Pharmacology Nursing Public Health

Description

Jurnal Kesehatan dr. Soebandi (JKDS) is a national journal covering scientific studies in various health fields (Nursing, Midwifery, and Pharmacy). Jurnal Kesehatan dr. Soebandi is a scientific journal as a forum for academics and practitioners to present quantitative and qualitative scientific ...