Background: Surgical Site Infections (SSI) are post-operative infections often caused by ESKAPE pathogens. These multidrug-resistant bacteria, identified by the WHO as a critical threat, typically result in severe wound infections and extended hospital stays. Case Presentation: A case of a 26-year-old male with an incisional surgical site infection (SSI) in the suprapubic area that worsened due to various management errors, prolonging the patient's wound healing, but was successfully managed with a holistic approach by a multidisciplinary team, including nutritional improvement, wound care, and rational antibiotic use, which were crucial for the success of the therapy. Conclucion: Effective management of ESKAPE-related SSIs requires targeted diagnostics, a holistic multidisciplinary strategy, and robust antimicrobial stewardship programs to improve outcomes.
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