Cardiovascular disease (CVD) is the highest cause of death globally, with coronary artery disease (CAD) as its manifestation. Multivessel disease (MVD), which involves two or more coronary vessels, has a higher risk of major cardiovascular events and long-term mortality than single-vessel disease (SVD). This study aims to determine the significant risk factors for the occurrence of MVD. The retrospective cross-section research design was carried out by analyzing medical record data of 122 patients who underwent coronary angiography (CAG) at Karawang Hospital in June-December 2023. Chi-square analysis was used for the identification of risk factors associated with MVD, and variables with p<0.025 were further analyzed using multivariate logistic regression. Results showed that diabetes mellitus (62.3%) and hypertension (50.0%) were the main risk factors, with a significant association between the two with the incidence of MVD (p=0.019 for hypertension, p=0.022 for diabetes). Logistic regression revealed that diabetes mellitus (OR=3.06; p=0.027) and hypertension (OR=3.72; p=0.015) were independent predictors of MVD incidence. Dyslipidemia showed no significant association (OR=1.89; p=0.271), likely as a result of the use of statin therapy. These findings confirm the importance of early detection, control of metabolic risk factors, and lifestyle modification in the prevention of MVD.
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