This study aimed to analyze the association factors between age, FOUR Score, and ICU length of stay among post-craniotomy patients treated at Sakinah Hospital. A cross-sectional study was conducted from 01 October to 12 December 2025 involving adult post-craniotomy patients admitted consecutively to the ICU. Eligible participants were ≥18 years old, intubated postoperatively, and had a completed FOUR Score assessment. Fisher’s Exact Test and relative risk (RR) with 95% confidence intervals (CI) were applied to examine associations between age, FOUR Score, and ICU LOS. A significance level of p < 0.05 was used. 29 patients, 58.6% were aged ≥53 years and 62.1% experienced prolonged ICU stay. A FOUR Score ≤10 was observed in 58.6% of the cohort. Lower FOUR Scores were strongly associated with prolonged ICU stay (p < 0.000; RR = 9.7; 95% CI: 1.4–63.8). Older age also demonstrated a significant association with extended LOS (p = 0.018; RR = 2.47; 95% CI: 1–7.7). Both advanced age and lower FOUR Scores were significant associated with prolonged ICU stay among post-craniotomy patients. These findings underscore the utility of integrating neurological scoring with demographic risk profiling to support early prognostication and guide resource allocation in neurosurgical critical care.
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