<![CDATA[This bibliometric analysis examines the evolving trends of digital transformation (DT) and information systems (IS) in U.S. businesses. It explores how technology—focused on strategy, efficiency, innovation, and customer engagement—is reshaping organizations and workplaces. Using a PRISMA-based systematic review and data from Scopus (2016–2026), the study applies the Bibliometrix R package to assess publication patterns. Results show significant growth, with 2,692 documents reflecting a 43.58% annual increase and 18.39% involving international collaboration. Key themes include AI/ML integration in business processes, digital sustainability, and IS as a strategic driver for business model evolution. U.S. businesses are increasingly aligning digital transformation with sustainability goals. This study addresses a key research gap by offering detailed insights into DT and IS impacts on operations and sustainability practices. It underscores the need for integrated socio-technical strategies, responsible data governance, and global collaboration to foster innovation and bridge digital divides.]]>
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