<![CDATA[Background: Systemic Lupus Erythematosus (SLE) is an autoimmunerheumatic disease characterized by widespread inflammation involvingalmost all organ systems. This disease attacks young women with apeak incidence aged 15-40 years. The clinical manifestations of SLEvary depending on the organs involved. The risk of death in SLEpatients increases if it is not diagnosed and treated appropriately.Methods: This study is a retrospective cohort study using medicalrecord data from patients diagnosed with SLE for the first time in 20142019 at RSCM. Survival analysis was carried out on age, gender,hemolytic anemia, thrombocytopenia, NPSLE, high anti ds-DNA, lowC3 and C4, high dose glucocorticoids, lymphopenia, positive AntiCardiolipin Antibody (ACA), cardiovascular disease, and lupusnephritis. Multivariate analysis with cox regression was carried out.Results: There were 448 subjects studied. The five-year survival of SLEpatients at RSCM is 88%. Mean survival 56 months (95% CI : 55-57).In the multivariate analysis, it was found that NPSLE [p=0,000 ; HR3,595 (95%CI 1,932-6,688)], low C3 and C4 [p=0,004 ; HR 2,501(95%CI 1,330-4,701)], cardiovascular disease [p=0,018 ; HR 2,851(95%CI 1,198-6,787)], and hemolytic anemia [p=0,023 ; HR 2,106(95%CI 1,008-4,404)] had a significant effect on patient survival.Conclusion: The 5-year survival of SLE patients was 88% withneuropsychiatric lupus (NPSLE), low C3 dan C4, cardiovasculardisease, dan hemolytic anemia have a significant effect on the SLEsurvival patients at RSCM.]]>
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