<![CDATA[Leukemia is a hematological malignancy characterized by abnormal proliferation of hematopoietic precursor cells in the bone marrow and an increased number of abnormal white blood cells in peripheral circulation. Early detection is crucial to reduce morbidity and mortality rates, one of which can be achieved through the use of hematology analyzers that display scattergrams. This study aimed to analyze the relationship between scattergram patterns from the Sysmex XN-1000 Hematology Analyzer and peripheral blood smear findings in leukemia patients. A descriptive cross-sectional design with total sampling was employed, involving 13 leukemia patients who underwent complete blood count using the Sysmex XN-1000 and peripheral blood smear examination at Dr. Wahidin Sudirohusodo Hospital, Makassar, from March to May 2019. Data were analyzed descriptively based on the distribution of gender, age, type of leukemia, laboratory results, and scattergram patterns. The results showed that most patients were male (84.6%), the most common age group was 21–40 years (38.5%), and the most frequent leukemia types were Acute Lymphoblastic Leukemia (46.2%) and Chronic Myeloid Leukemia (46.2%). Scattergram analysis revealed distinct patterns for each leukemia type: predominance of high-fluorescence lymphocytes with an inverted comma pattern in ALL, variable-sized myeloid blasts overlapping with granulocytes and monocytes in AML, and granulocytic dominance with immature granulocyte values >10% in CML. These scattergram patterns were consistent with peripheral blood smear findings, supporting their role as an early indicator of hematologic abnormalities. In conclusion, scattergrams from the Sysmex XN-1000 have potential as a rapid and informative screening tool prior to microscopic confirmation in leukemia cases.]]>
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