Monkey Pox is a disease caused by a virus with the genus orthopoxvirus that can infect humans. The initial symptoms of this disease are the appearance of lumps due to swollen lymph nodes, muscle pain, fever, feeling tired and weak. Although similar to Chickenpox, Monkey Pox is clinically difficult to distinguish from other smallpox diseases. This study aims to classify Monkey Pox disease using the "Monkey-Pox PATIENTS Dataset". Classification of Monkey Pox disease is done using Random Forest and Naïve Bayes methods. Random Forest produces higher accuracy than Naïve Bayes in classifying Monkey Pox disease, which is 69.24% with a k-fold value of 5 and the number of trees 64 using an unbalanced dataset with 6 attributes. While Naïve Bayes produces an accuracy of 68.56% using a dataset without balancing with 8 attributes (k-fold=5, kernel=Gaussian) and 9 attributes (k-fold=3 and 10, kernel=Gaussian).
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