<![CDATA[Colorectal cancer remains one of the leading causes of death worldwide, where early detection of polyps through colonoscopy plays a vital role in prevention. This study aims to enhance polyp segmentation performance by integrating Attention U-Net with Contrast Limited Adaptive Histogram Equalization (CLAHE) as a preprocessing technique. The proposed method was evaluated using two benchmark datasets, CVC-ClinicDB as the primary dataset and Kvasir-SEG for cross-domain testing. The model was trained using a combination of Binary Cross-Entropy and Dice losses, with a 70–15–15 split for training, validation, and testing. Experimental results show that applying CLAHE improves segmentation accuracy, achieving Dice and IoU scores of 0.84 and 0.76 on CVC-ClinicDB, and 0.62 and 0.50 on Kvasir-SEG, respectively. Statistical analysis using the Wilcoxon signed-rank test confirmed a significant difference between the baseline and enhanced models. These findings demonstrate that the integration of CLAHE with Attention U-Net effectively improves boundary detection and robustness against illumination variations across datasets, contributing to more accurate and reliable computer-aided diagnosis in colorectal cancer screening.]]>
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