Keberhasilan Kumur Doksisiklin sebagai Terapi Awal pada Kasus Periodontitis Stadium III Grade C

Ernie Maduratna Setiawatie (Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya)
Ferlina Diah Ayu Yosi Pramita Asano (Resident of Periodontology Specialist Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya)
Esi Yuniza Fitrina (Resident of Periodontology Specialist Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya)

Yarsi Dental Journal
Vol. 3 No. 2 (2026): YARSI DENTAL JOURNAL

Introduction: Periodontitis progressively destroys tooth-supporting tissues. Conventional oral therapies often cause systemic side effects and fail to reach therapeutic levels in periodontal pockets. Doxycycline, studied for its local antimicrobial and anti-inflammatory effects, was used here as a 0.1% gargle. Case report: A 58-year-old woman presented with upper left tooth mobility, chewing pain, discomfort, and bleeding on brushing. Treatment included education, scaling/root planing, splinting, and twice-daily 0.1% doxycycline gargle post-brushing. After 2 months, gingival consistency had firmed, color had normalized, tooth mobility had reduced, and pocket depths had decreased. Discussion: Doxycycline inhibits subgingival pathogens and binds to dentin for sustained bacteriostatic action. It also suppresses collagenases (MMPs) from neutrophils and bacteria. Conclusion: In this case, 0.1% doxycycline gargle reduced gingival inflammation and improved clinical parameters as initial therapy before surgery, suggesting potential as a low-cost adjunct.