Troponin Profile Of Clopidogrel And Ticagrelor With Old Generation PPIs In Myocardial Infarction Patients

Erlisa Ika Yuni Pramesti
Kharisma Jayak Pratama
Hidayah Apriliawan

International Journal of Health, Engineering and Technology
Vol. 4 No. 6 (2026): IJHET MARCH 2026

Myocardial infarction is a leading cause of cardiovascular death in Indonesia with an increasing prevalence. The interaction of clopidogrel-ticagrelor with older-generation PPIs can affect antiplatelet efficacy and troponin levels. This study aims to describe troponin levels in the use of clopidogrel and ticagrelor with older-generation PPIs and their relationship to patient characteristics and lipid profiles. A retrospective descriptive observational method was conducted on 76 myocardial infarction patients at March eleventh University Hospital (November 2024-November 2025) using medical record data. Univariate (frequency, mean) and bivariate (Chi-Square, p<0.05) analyses were processed using SPSS. The results showed that the majority of patients were male (66%), aged 46-65 years (64%). There was no significant association between gender (p=0.542), age (p=0.415), clopidogrel-PPI (p=0.346), ticagrelor-PPI (p=0.368), and LDL (p=0.100) with troponin, but triglycerides were significantly associated (p=0.040). The average troponin of clopidogrel was 9.465 ng/L, higher than that of ticagrelor (3.879 ng/L). It was concluded that triglycerides significantly influenced troponin, while patient characteristics and the combination of antiplatelet-PPI did not.