Correlation between Neutrophil Lymphocyte Ratio (NLR) and Myocardial Infarction Severity (STEMI and NSTEMI) in Patients Admitted to Dr. Mohammad Soewandhi Hospital

Adnyani, Ida Ayu Tia Putri
Santosa, Rahajoe Imam
Handari, Saskia Dyah

Jurnal Biomedika dan Kesehatan
Vol 9 No 1 (2026)

Acute cardiac Infarction (AMI) is a disorder characterised by the necrosis of cardiomyocytes resulting from a disparity between cardiac demand and oxygen delivery. The primary aetiology of IMA is thrombotic occlusion resulting from a ruptured atherosclerotic plaque. IMA is categorised into two types: STEMI and NSTEMI. In STEMI patients, entire occlusion results in increased severity, namely transmural infarction affecting all layers of the heart wall, in contrast to NSTEMI patients, who have partial occlusion. Myocardial infarction elicits an inflammatory response to eliminate necrotic cardiomyocytes and residual matrix debris, facilitating scar tissue formation and the commencement of the healing process. During inflammation, there is a change in leukocyte values characterised by an increase in neutrophil count, indicative of an initial inflammatory response, followed by a drop in lymphocyte count, suggesting a stress response, ultimately culminating in an elevated Neutrophil Lymphocyte Ratio (NLR).