<![CDATA[Introduction: Osteoarthritis (OA) is a degenerative joint disease that causes pain, inflammation, and impairment in physical functions. Antioxidants, which neutralize free radicals, have shown potential in modulating inflammatory responses associated with OA. Vitamin E can suppress IL-1β-induced toxicity of chondrocytes, preserving cartilage integrity. However, further investigation is needed to determine their efficacy in diverse populations and conditions, such as osteoarthritis (OA). Methods: The search was conducted across five databases: PubMed, Cochrane, Epistemonikos, Scopus, and ProQuest, as well as EBSCO, up to January 2025. Eligibility criteria included data availability in a compatible language, inclusion of intervention studies, involvement of animal or human samples with knee osteoarthritis, utilization of antioxidants for efficacy outcomes, and consideration of at least the interleukin-1 beta parameter. Results: The study thoroughly evaluated 13 studies, removing duplicates and conducting an initial screening of abstracts, and assessed their demographics and clinical characteristics. Six studies were evaluated using the RoB 2.0 tool for randomized clinical trials, and seven studies were assessed using the SYRCLE tool for animal trials. All studies have a low risk of bias. Conclusion: Antioxidants are effective in treating knee osteoarthritis (OA) compared to a placebo, but dosage is crucial for optimal results. Further safety studies are needed.]]>
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