<![CDATA[Background: Anti-obesity drugs are associated with adverse side effects; therefore, non-pharmacological approaches without side effects, such as regulating dietary patterns and engaging in physical activity, are more strongly recommended for obesity management. Consequently, supportive therapies such as pulsed electromagnetic field (PEMF) exposure are needed to maximize the recovery potential of individuals with obesity. Obesity leads to an abnormal increase in the number and size of white adipose tissue through the differentiation of new adipocytes (adipogenesis). Objective: This study aimed to determine the molecular effects of PEMF exposure by examining the expression of ZFP423 and PPARG in obese mice. This research was conducted as an effort to contribute to the reduction of obesity prevalence. Methods: This experimental study used male C57BL/6J mice induced to become obese through a high-fat diet. The mice were exposed to PEMF for 2, 7, 14, and 21 days. The parameters assessed included the expression of ZFP423 and PPARG using qRT-PCR. Results and Discussion: C57BL/6J mice developed obesity following high-fat diet administration, as indicated by a Lee index value > 0.310. The expression levels of ZFP423 and PPARG genes relative to the control gene β-Actin showed a decrease after 2 days of exposure. ZFP423 expression increased again after 7, 14, and 21 days of exposure, whereas PPARG expression continued to decline at 7, 14, and 21 days of exposure. Conclusion: PEMF exposure reduced ZFP423 expression in obese mice exposed for 2, 7, 14, and 21 days compared to obese mice without exposure. In addition, PEMF decreased PPARG expression in obese mice across all exposure durations when compared to non-exposed obese mice, although these differences were not statistically significant.]]>
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